Professor of Systems Pharmacology
Room 129A
M Floor
The Royal Hallamshire Hospital
Sheffield
S10 2JF
Tel: +44 (0)114 271 2156
Email: a.rostami@sheffield.ac.uk
Tel, PA Susan Lundie: +44 (0)114 292 2324
Fax: +44 (0)114 292 2333
Email PA: s.lundie@simcyp.com
Research Interests
- Applications of "systems biology" approach to prediction of drug absorption, distribution and elimination.
- Extrapolation of in vitro data on drug metabolism to predict in vivo pharmacokinetics and pharmacodynamics.
- Applications
of PKPD in endocrinology, drug abuse, child health and paediatric
pharmacology, clarifying the role of differences in drug metabolism on
drug response.
- Theoretical aspects of metabolic biomarkers.
Activities and Distinctions
- Author/co-author of over 80 peer-reviewed full articles; overall citations received (CR) 1050 by April 2008.
- Invited
speaker in over 40 national and international meetings in the area of
modelling in clinical pharmacology, drug metabolism and
pharmacogenetics.
- Elected Scientific
Secretary of PKUK, the UK discussion group on pharmacokinetics; and
serving on the editorial boards of the Br J Clin Pharmacol, J
Pharmacokin Pharmacodyn, Xenobiotica, Drug Metabolism and
Pharmacokinetics, Current Drug Metabolism, Acta Pharmaceutica Sciencia,
Biopharmaceutics and Drug Disposition, Drug Metabolism Letters.
- Currently
leading a 20 member science team (14 holding PhD degrees) as Director
of Scientific Research and Development (75% time secondment) at Simcyp
Limited, one of the most successful spin-off companies of the Medical
School at the University of Sheffield.
- Recipient
of the EUFEPS (European Federation of Pharmaceutical Sciences) 2004
award for "New Sage Medicines Faster" initiative (jointly with
Professor Geoff Tucker).
Representative Publications
Van LM, Sarda S, Hargreaves JA and Rostami-Hodjegan A.
Metabolism of Dextrorphan by CYP2D6 in Different Recombinantly
Expressed Systems and its Implications for the In Vitro Assessment of
Dextromethorphan Metabolism, J Pharm Sci (in press)
Yang J et al.
Cytochrome P450 turnover: Mechanisms, methodologies for determination ,
and implications for the prediction of clinical drug interactions, Curr
Drug Metab 2008 (in press)
Ghobadi C, Amer S, Lashen H, Ledger WL, Lennard MS and Rostami-Hodjegan A.
Evaluation of the relationship between plasma of en- and zuclomiphene
and induction of ovulation in anovulatory women being treated with
clomiphene Citrate, Fertil Steril (Epub ahead of print)
Ghobadi C, Gregory A, Crewe HK, Rostami-Hodjegan A
and Lennard MS. CYP2D6 is primarily responsible for the metabolism of
clomiphene, Drug Metabolism and Pharmacokinetics (in press)
Johnson TN, Tucker GT, Rostami-Hodjegan A. Development of CYP2D6 and CYP3A4 in the First Year of Life, Clinical Pharmacology & Therapeutics 2007 (Epub ahead of print)
Newell-Price J, Whiteman M, Rostami-Hodjegan A,
Darzy K, Shalet S, Tucker GT, Ross RJM. Modified-Release Hydrocortisone
for Circadian Therapy: A Proof of Principle Study in
Dexamethasone-Suppressed Normal Volunteers, Clin Endocrin 2008, 68 (1): 130-135
Venkatakrishnan K, Obach, RS, Rostami-Hodjegan A.
Mechanism-based inactivation of human cytochrome P450 Enzymes:
strategies for diagnosis and drug-drug interaction risk, Xenobiotica
2007, 37(10&11): 1225-1256
Gibson, GG, Rostami-Hodjegan A.
Editorial: Modelling and simulation in prediction of human xenobiotic
absorption, distribution, metabolism and excretion (ADME): in vitro–in
vivo extrapolations (IVIVE), Xenobiotica 2007 , 37: 1013-14
Kay L, Rostami-Hodjegan A,
Suvarna K, Peachell P. Influence of beta2-adrenoceptor gene
polymorphisms on beta2-adrenoceptor-mediated responses in human lung
mast cells. Brit J Pharmacol 2007, 152: 323-331
Perrett H, Barter Z, Jones B, Yamazaki H, Tucker G, Rostami-Hodjegan A.
Disparity in Holo/Apoprotein Ratios of Different Standards Used for
Immuno-quantification of Hepatic Cytochrome P450 Enzymes. Drug Metab
Dispos 2007, 35 (10): 1733-1736
Current Grants
EU Framework 6 [(1) BIOSIM, (2) LINTOP], Simcyp Ltd, EU Framework 7 (Predict-IV).
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Professor Amin Rostami-Hodjegan 
